Are mesenchymal stem cells distinct from hematopoietic stem cells?
In vitro studies over many years established the essential role of bone marrow stromal cells for the development and differentiation of hematopoietic cells in vitro. The distinct lineage origin of such stromal cells was elegantly demonstrated by Simmons and colleagues, who showed that these cells isolated from patients with functioning sex-mismatched but HLA-identical allografts were exclusively of host genotype (Simmons et al. 1987). This finding clearly indicated that stromal cells supporting hematopoiesis are a population distinct from hematopoietic cells, and thus confirmed in vivo previous observations from Friedenstein’s laboratory, which showed that in sex-matched transplants cells capable of forming heterotopic osseous tissue were physically different from HSCs (Friedenstein, 1980). An important implication of this discovery was that mesenchymal stem cells, which according to the work of Friedenstein and colleagues also give rise to stromal cells supporting hematopoiesis, were
Related Questions
- Why do some stem cell facilities around the world require days to weeks before removal of mesenchymal stem cells until reinsertion into the patient?
- We freeze hematopoietic stem cells and we getm uch higher viabilities than other centers that use the same protocol. Why are our number different?
- Are there reports of autologous adipose derived adult mesenchymal stem cells harming any humans or animals?
