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Are men with larger prostates and bothersome voiding symptoms less likely to have significant prostate cancer?

April 26, 2017bothersome larger likely men prostate cancer prostates SIGNIFICANT symptoms voiding

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Are men with larger prostates and bothersome voiding symptoms less likely to have significant prostate cancer?

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C. R. Porter, J. Wright, L. Borden, K. Jason and K. Latchemsetty Virginia Mason, Seattle, WA; Stony Brook University, Stony Brook, NY 4656 Background: Gleason Sum (GS) predicts clinically significant prostate cancer (CAP) and prostate specific antigen (PSA) survival in men undergoing prostatectomy for CAP. BPH can also elevate PSA. Objective: evaluate prostate gland volume (PV) and American Urologic Symptom Score (AUASS) in men undergoing prostate needle biopsy (PNB) to detect CAP. Analysis endpoints: 1) CAP and 2) GS 7. Methods: From 1/2000 7/2005, 1,078 men undergoing PNB were prospectively examined. Urinary voiding symptoms were measured by AUASS. All men were examined by 1 surgeon: DRE and Transrectal Ultrasound (TRUS) were given levels of suspicion (LOS) from 1 = low suspicion (smooth DRE, homogeneous TRUS) to 5 = high suspicion (hard DRE, hypoechoic lesion). LOS 3 was abnormal. Prebiopsy parameters: PSA, DRE, age, race, biopsy history, prostate volume (PV), TRUS lesion, and AUASS