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Are Mast Cells a Biologic Predictor of Outcome in Follicular Lymphoma?

April 26, 2017Biologic cells follicular follicular lymphoma lymphoma Mast outcome predictor

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Are Mast Cells a Biologic Predictor of Outcome in Follicular Lymphoma?

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Monday, December 8, 2008, 5:30 PM-7:30 PM Hall A (Moscone Center) Poster Board III-854 Matthew T Howard1*, Brad Pohlman2, Tao Jin3* and Eric Hsi11Clinical Pathology, Cleveland Clinic, Cleveland, OH 2Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 3Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH Background: The tumor microenvironment is important in the biology of follicular lymphoma (FL). In addition to macrophages, which have been shown to be associated with outcome in FL, mast cells (MCs) have the ability to influence the microenvironment through secretion of numerous biologically active molecules such as growth factors and cytokines/chemokines. Increased numbers of tumor-infiltrating MCs have been suggested as an unfavorable prognostic marker that also supercedes the predictive value of lymphoma-associated macrophages (LAM) in FL patients treated with immunochemotherapy. This study examines the effects of tumor-infiltr