Are major multiple survival surgical procedures permitted on a single animal?
The Guide discourages multiple major survival surgical procedures on a single animal but provides that if scientifically justified by the user and approved by the IACUC they may be permitted. Guide examples of justifications include (1) procedures that are related components of a research project; (2) conservation of scarce animal resources, and (3) clinical necessity. The Guide does not consider cost savings alone an adequate reason for performing major multiple survival surgical procedures. [A7] Note that under the AWA regulations, major multiple survival surgical procedures are permitted only if the multiple procedures are included within one proposal, justified for scientific reasons, and approved by the IACUC. The AWA requires prior authorization of the USDA Administrator, Animal and Plant Health Inspection Service, for an exemption from this requirement. [See 9 CFR, Part 2, Section 2.
The Guide discourages multiple major survival surgical procedures on a single animal but provides that if scientifically justified by the user and approved by the IACUC they may be permitted. Guide examples of justifications include (1) procedures that are related components of a research project; (2) conservation of scarce animal resources, and (3) clinical necessity. The Guide does not consider cost savings alone an adequate reason for performing major multiple survival surgical procedures. [A7] Note that under the AWA regulations, major multiple survival surgical procedures are permitted only if the multiple procedures are included within one proposal, justified for scientific reasons, and approved by the IACUC. The AWA requires prior authorization of the USDA Administrator, Animal and Plant Health Inspection Service, for an exemption from this requirement. [See 9 CFR, Part 2, Section 2.31 (d)(1)(x)] • May the IACUC approve deviations from the Guide for rodent (mice and rats) cage d
