Are Lesions the Only Abnormality That Can Indicate MS?
No. There is the situation that T-Lynn, here on the forum, had. She had years of symptoms, but no “lesions” on MRI. However, she obviously had a huge load of invisible lesions. Her first positive MRI finding was “brain atrophy.” There had been so many “invisible lesions” that eventually large amounts of brain tissue was destroyed and it became obvious on MRI that her brain had actually shrunk. It is not routine to do the special computer calculations that show early brain atrophy, but in her case that would have alerted her doctors much earlier to the atrophy before it became painfully obvious. In all fairness, a doctor cannot use invisible lesions to make a diagnosis. We can’t ask them to.