Are H1N1 influenza viruses resistant to oseltamivir (Tamiflu)?
A small number of patients worldwide have been infected with a H1N1 influenza (flu) virus that is resistant to the antiviral drug oseltamivir (Tamiflu). To date, the oseltamivir-resistant viruses have been sensitive to zanamivir (Relenza). At this time, CDC continues to recommend the use of oseltamivir or zanamivir to prevent or treat H1N1 infection. The illnesses caused by oseltamivir-resistant viruses have been similar to those caused by oseltamivir-sensitive viruses. CDC continues to monitor H1N1 flu viruses for antiviral resistance. Among the 202 H1N1 viruses from the U.S. tested by CDC this year, none have been resistant to oseltamivir.
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