Are endogenous NGF functions impaired in apoE KO mice?
Because sprouting was evoked in these animals by injected NGF but not by the assumed endogenous NGF stimulus in adjacent denervated skin, we focused our investigations on the anticipated impairments of endogenous NGF-related functions. We found none. First, NGF protein levels in innervated apoE KO mouse skin were normal, and they increased normally after skin denervation (Fig. 3a). Second, axonal transport of NGF occurred normally from innervated skin, and increased normally in nerves adjacent to denervated skin (Fig. 3b). Third, the expression in the DCNs of p75, and both the expression and phosphorylation of trkA, were comparable in apoE KO and wild-type mice (Fig. 4a,b), but in some paired specimens there was a trend, which failed to reach significance, of an increased expression of p75 in apoE KO DCNs (data not shown). After denervation of adjacent skin, the intensity of both unphosphorylated and phosphorylated trkA signals were not significantly different in the DCNs of the two an
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