Are dendritic cells the key to liver transplant tolerance?
The inherent tolerogenicity of liver allografts could be due to the organ’s combination of hematopoietic activity, production of growth-promoting and immunoregulatory cytokines, and comparatively large numbers of potentially tolerogenic antigen-presenting cells, in particular dendritic cells (DCs). Here, Angus Thomson and Lina Lu consider the evidence that DCs can subvert allogeneic T-cell responses and might be exploited therapeutically to prolong graft survival.
