Are Cox-2 inhibitors less likely to irritate the stomach than older antiinflammatory drugs?
Dr. Shiel Selective Cox-2 inhibitors (such as Celebrex and Bextra) NOTE: April 7, 2005, Pfizer has agreed to suspend sales and marketing of Bextra in the U.S., pending further discussions with the with the FDA. For more information, please read the FDA press release. , do not inhibit the Cox-1 enzyme in the stomach and are thus felt to be less toxic to the stomach than traditional antiinflammatory drugs (such as aspirin, ibuprofen, or naproxen). These traditional anti-inflammatory drugs, called nonselective Cox-1/Cox-2 inhibitors, inhibit both Cox-1 and Cox-2 enzymes. While inflammation is reduced by blocking Cox-2, the protective mucus lining of the stomach is also reduced when Cox-1 is blocked, which can cause stomach upset, ulcers, and bleeding. Current evidence suggests that the selective Cox-2 inhibitors are less toxic to the stomach than traditional antiinflammatory drugs. This effect is especially significant in persons who are at risk of stomach bleeding, such as those with a h
Dr. Shiel Selective Cox-2 inhibitors (such as Celebrex and Bextra) NOTE: April 7, 2005, Pfizer has agreed to suspend sales and marketing of Bextra in the U.S., pending further discussions with the with the FDA. For more information, please read the FDA press release. , do not inhibit the Cox-1 enzyme in the stomach and are thus felt to be less toxic to the stomach than traditional antiinflammatory drugs (such as aspirin, ibuprofen, or naproxen). These traditional anti-inflammatory drugs, called nonselective Cox-1/Cox-2 inhibitors, inhibit both Cox-1 and Cox-2 enzymes. While inflammation is reduced by blocking Cox-2, the protective mucus lining of the stomach is also reduced when Cox-1 is blocked, which can cause stomach upset, ulcers, and bleeding. Current evidence suggests that the selective Cox-2 inhibitors are less toxic to the stomach than traditional antiinflammatory drugs. This effect is especially significant in persons who are at risk of stomach bleeding, such as those with a h
Related Questions
- Are Cox-2 inhibitors better pain relievers than older, traditional anti-inflammatory drugs like ibuprofen and naproxen?
- Which patients are prescribed COX-2 inhibitors rather than nonspecific anti-inflammatory drugs?
- Are Cox-2 inhibitors less likely to irritate the stomach than older antiinflammatory drugs?
