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Are Chemically Reactive Metabolites Responsible for Adverse Reactions to Drugs?

April 26, 2017adverse chemically drugs Metabolites reactions reactive responsible

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Are Chemically Reactive Metabolites Responsible for Adverse Reactions to Drugs?

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Pp.351-366 D.P. Williams, N.R. Kitteringham, D.J. Naisbitt, M. Pirmohamed, D.A. Smith and B.K. Park [Abstract] Mechanism of Idiosyncratic Drug Reactions: Reactive Metabolites Formation, Protein Binding and the Regulation of the Immune System Pp.367-377 C. Ju and J.P. Uetrecht [Abstract] On the Diversity of Oxidative Bioactivation Reactions on Nitrogen-Containing Xenobiotics Pp.379-424 Amit S. Kalgutkar, Deepak K. Dalvie, John P. O’Donnell,Timothy J. Taylor, and Diana C. Sahakian [Abstract] The Metabolism and Toxicity of Quinones, Quinonimines, Quinone Methides, and Quinone-Thioethers Pp.425-438 Terrence J. Monks and Douglas C. Jones [Abstract] Xenobiotic Acyl Glucuronides and Acyl CoA Thioesters as Protein-Reactive Metabolites With the Potential to Cause Idiosyncratic Drug Reactions Pp.439-450 Urs A.