Are CD4 decays affected after transmission of drug-resistant viruses in HIV recent seroconverters?
de Mendoza C, Ortiz M, Perez-Hoyos S, Garcia-Saiz A, del Amo J, del Romero J, Soriano V, Rodriguez C; Madrid Seroconverters Study Group; International Conference on AIDS (15th : 2004 : Bangkok, Thailand). Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. WePeB5743. Hospital Carlos III, Madrid, Spain Background: HIV drug-resistant strains have been associated with a partial preservation of CD4 counts in patients failing antiretroviral therapy. Viruses with a lower replication capacity (RC) due to drug resistance mutations might result in a lower depletion of CD4 cells, even in drug-naive individuals. We assessed the impact of transmission of drug-resistant viruses on the decay of CD4 counts in subjects with proven date of HIV seroconversion. Methods: All persons with a prior negative HIV test who subsequently seroconverted for HIV antibodies were included in the cohort. A genotypic test was performed at the first HIV+ specimen. Demographics, virologic and immunologic data were collected a
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