Are caspases activated in bile salt–mediated apoptosis, and does caspase inhibition reduce apoptosis?
Immunoblot analysis demonstrated that PARP and lamin B1, two substrates cleaved by caspases in many models of apoptosis, were also cleaved in GCDC-treated McNtep.24 cells (Fig. 2). These results suggested that, in addition to cathepsin B, caspases are activated in GCDC-induced hepatocyte apoptosis.
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