ARE CARCINOGENS RESPONSIBLE FOR THE SUPERIMPOSED NEOPLASTIC CHANGES OCCURRING IN MOUSE TUMOR CELLS?
: THE EFFECT OF METHYLCHOLANTHRENE AND URETHANE ON PULMONARY ADENOMAS AND OF METHYLCHOLANTHRENE ON MAMMARY CARCINOMAS Keith Dumbell M.D.1 and Peyton Rous M.D.1 1 From The Rockefeller Institute for Medical Research Three spontaneous pulmonary adenomas of C mice, morphologically resembling those induced by methylcholanthrene or urethane, were propagated in host after host under conditions such that the neoplastic cells were directly exposed, while proliferating, to one or the other of these agents. The successive periods of test lasted for more than a year in some instances, the total exposure to the carcinogens far exceeding that required to change normal pulmonary cells into adenoma cells. One of the adenomas remained unaltered, and the others underwent cancerous changes; but these took place with equal frequency in the control growths, and their occurrence was neither hastened nor delayed by the carcinogens. Two polymorphous mammary carcinomas of “milk-factor” type, with the character
Related Questions
- After a few hours of incubation, the behaviour of my cells changes significantly and the amount of media is reduced. What can I do against this strong evaporation?
- ARE CARCINOGENS RESPONSIBLE FOR THE SUPERIMPOSED NEOPLASTIC CHANGES OCCURRING IN MOUSE TUMOR CELLS?
- Who is ultimately responsible for rules changes?
