Are apple polyphenols safe?
Yes. A study published in June 2004 in Food and Chemical Toxicology tested oral toxicity of apple polyphenol extracts at levels 200 times the recommended dosage for humans. Researchers reported “no significant hematological, clinical, chemical, histopathological, or urinary effects” even at these extreme dosages. Apple polyphenol extracts are listed (as “apple essence, natural”) in the FDA’s approved additive/GRAS (Generally Recognized As Safe) database.