Are Apgar scores lower in neonates born to WWE?
Conclusion • Neonates of WWE taking AEDs possibly have an increased risk of 1-minute Apgar scores of <7 of about twice the expected rate (one Class II study). Recommendation • Pregnancy risk stratification should reflect that the offspring of WWE taking AEDs during pregnancy possibly have an increased risk of 1-minute Apgar scores of <7. Further, AED use in WWE during pregnancy may be considered in the differential diagnosis of a 1-minute Apgar score of <7 in their offspring (Level C). Definitions: Classification of Recommendations The strength of practice recommendations is linked directly to the level of evidence: Level A = Established as effective, ineffective, or harmful (or established as useful/predictive or not useful/predictive) for the given condition in the specified population. (Level A rating requires at least two consistent Class I studies.*) Level B = Probably effective, ineffective, or harmful (or probably useful/predictive or not useful/predictive) for the given conditi
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