Are any premedications recommended prior to Clolar administration?
Antiemetics should be considered to prevent possible nausea/vomiting. Prophylactic steroids (e.g., 100 mg/m2 hydrocortisone on days 1 through 3) may be of benefit in preventing signs or symptoms of systemic inflammatory response syndrome (SIRS)/capillary leak syndrome (e.g. tachypnea, tachycardia, hypotension, pulmonary edema). If hyperuricemia is expected, allopurinol should be administered prophylactically. Clolar should be discontinued immediately in the event of clinically significant signs or symptoms of SIRS or capillary leak syndrome, either of which can be fatal, and use of steroids, diuretics, and albumin considered.
