Are antidepressant medications effective in reducing transition to full threshold psychosis in a UHR (putatively prodromal) population?
Individuals presenting with an “at risk mental state” (otherwise known as an Ultra High Risk (UHR) psychosis population) are at a greatly increased risk for developing a frank psychosis than the general population. This has led to efforts to investigate treatments that will stop or delay a “transition” to a fully psychotic state. Authors have suggested that antidepressants such as SSRI’s may be effective in the role, although there has not been a randomized controlled trial undertaken in this population as it could be seen as unethical to withhold antidepressant treatment from a group who have a particularly high rate of depression. One way of further investigating the effectiveness of these medications would be to conduct a naturalistic study comparing those prescribed antidepressants and those not controlling for potential confounders. The proposed study will collect data on antidepressant use from a larger multi-site trial comparing omega 3 fish oil fish to placebo. It will be possi
