Are all of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) criteria presented in the guidance equally important in the evaluation of new methods?
No. Certain criteria are considered more important than others. For example, the criterion to demonstrate a linkage between the new test and an existing test (i.e., correlation of an in vitro method with an in vivo method) may weigh more heavily than the other criteria when evaluating new methods. Correlation does not imply that a 1:1 correlation between in vitro and in vivo assays is required, only that the in vitro bioaccessibility method be predictive of in vivo bioavailability.
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