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A recently published study (Eddleman, 2006) suggests that the risk of post-procedure loss after amniocentesis is not as high as previously identified. Is that true?

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A recently published study (Eddleman, 2006) suggests that the risk of post-procedure loss after amniocentesis is not as high as previously identified. Is that true?

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There were significant issues associated with the design of the study. A more recent expert committee review (Wilson, 2007) reported that the best estimated range to consider for an increased rate of pregnancy loss attributable to amniocentesis is 0.6% to 1.0% (1:175 or 1:100) but may be as low as 0.19% or as high as 1.53% on the basis of the confidence intervals (CI) seen in the various studies. The best risk estimate for twin pregnancies was identified as 1.6% (CI 0.3-3%) (Wapner, 1993). The review concludes that amniocentesis continues to be associated with a non-negligible risk of pregnancy loss.

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