How does Levofloxacin work?
Levofloxacin works by entering the bacterial cell and inhibiting a DNA-gyrase which is involved in the production of genetic material (DNA). This prevents the bacteria from reproducing and their growth is stopped. Levofloxacin versus Cefdinir The multicenter, double-blind study compared the efficacy and tolerability of cefdinir and levofloxacin in patients with acute rhinosinusitis. Clinical cure rates in the cefdinir and levofloxacin groups were 83% and 86%. The study have shown that cefdinir and levofloxacin have comparable efficacy in the treatment of infections classified as moderate to severe. The incidence of adverse events was generally comparable in the 2 treatment groups. However, cefdinir had greater rate of incidence of vaginal moniliasis in women (11% vs 0%), drug-related diarrhea (8% vs 1%). Levofloxacin had a higher incidence of insomnia (0% for cefdinir vs 4% for levoflxacin)1.
