dorsal root ganglion [?
. It stays there until reactivation. When it reactivates, it travels along the nerve fibres to the skin. The nerve fibres in the legs and buttocks stem from the same ganglia as the genital and anal regions. So the pain may be caused by reactivation of the virus traveling along the nerve fibres in the buttocks and legs. Very close examination of your genital and perianal region when this pain occurs may, or may not, identify small sores or areas of redness that are outbreaks of genital herpes. If your doctor thinks that your pain is caused by herpes, you may be prescribed antiviral therapy. Episodic antiviral therapy may help reduce the duration of these outbreaks, and suppressive therapy may help prevent or delay them from occurring.7,16,17 Naturally, your doctor will need to rule out other potential causes of your pain before prescribing antiviral therapy.