WHY THE SPINAL CORD?
The spinal cord contains complex neuronal circuits which are responsible for the first stage of processing of input from skin, muscle and viscera, including signals contributing to sensation of pain. Networks of neurons in the spinal cord also integrate sensory input and signals descending from the brain to generate the common motor output by which volitional movement and postural control are produced. The synaptic connections of the spinal cord are not well understood but it is a region of the central nervous system which is particularly amenable to experimental investigation as its inputs, outputs and internal circuitry are accessible to study. Over the past decade new approaches for investigating spinal cord circuitry have been developed and our knowledge of these circuits has increased considerably. Attempts to determine how neuronal networks in the spinal cord operate have two main goals; first to contribute to an understanding of the fundamental functioning of the vertebrate nerv
