How is EB inherited?
EB is passed to a child from the mother and/or father’s chromosomes. All of the genes that cause EB are autosomal, meaning the genes are not carried on the sex-determining (X and Y) chromosomes. Chromosomes are two sets of instruction manuals that contain information on how to make everything in your body. One instruction manual is from your mother and the other is from your father. Genes on chromosomes are like pages or sections of the instruction manual that focus on a specific part of the body, like eye color. In individuals with EB, some of the pages (genes) of one or both instruction manuals (chromosomes) are missing or incorrect. These pages should contain the instructions to make the proteins that hold the skin together. Faulty instructions lead to missing or abnormal proteins, and the skin is not as strong as it should be. One or two sets of bad instructions produce different forms of EB. Autosomal Dominant Inheritance Most forms of EB Simplex and Dominant Dystrophic EB are aut
