Why do homocysteine levels increase?
Bolander-Gouaille C. Springer 2002, 69-117 Focus on Homocysteine and the Vitamins Involved in its Metabolism, 2nd edition. Homocysteine and Cognitive Performance in the Framingham Offspring Study: Age Is Important Merrill F. Elias, Lisa M. Sullivan, Ralph B. D’Agostino, Penelope K. Elias, Paul F. Jacques, Jacob Selhub, Sudha Seshadri, Rhoda Au, Alexa Beiser and Philip A. Wolf American Journal of Epidemiology 2005 162(7):644-653. Abstract Plasma total homocysteine (tHcy) concentrations are associated with deficits in cognitive performance in persons free from dementia. The extent to which age modifies these associations is in need of further investigation in large, community-based, prospective studies combining the following elements: 1) multiple cognitive tests; 2) statistical adjustment for the role of the vitamin cofactors folate, vitamin B6, and vitamin B12; and 3) adjustment for the presence of risk factors for cardiovascular disease and stroke. Using data collected between 1991 an