How Is Didanosine Taken?
Didanosine is available in a slow-release capsule (Videx EC) in capsules of various strengths, and as a powder that is dissolved in water. Videx EC should be taken with an empty stomach. Do not chew it; swallow it whole. The recommended dose of didanosine is based on weight. For people weighing at least 20 kg (44 lbs.) but less than 25 kg (55 lbs.) the dose is 200 mg (milligrams) daily; more than 25 kg but less than 60 kg (between 55 and 132 lbs), 250 mg daily; and over 60 kg (132 pounds), the dose is 400 mg once a day. If you have had liver or kidney problems, the dose of didanosine may need to be reduced. The original form of didanosine could not be absorbed in an acid environment. It contained a buffer to reduce the effects of stomach acid. The original form of didanosine was taken on an empty stomach, 30 minutes before eating or two hours after a meal. Taking it with food reduced blood levels by as much as 50%.