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A COX-2 inhibitor works by blocking COX-2 enzymes in the body that trigger pain and inflammation. Traditional NSAIDs (Ibuprofen and aspirin) block both COX-2 and COX-1 enzymes. However, COX-1 enzyme protects the lining of the stomach, but can lead to stomach irritation. A COX-2 inhibitor relieves pain without irritating the stomach.
