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What are tricyclics?

April 26, 2017tricyclics

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What are tricyclics?

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Also called TCAs, tricyclics are old generation drugs that work by blocking the reuptake (or absorption by the neuron) of the neurotransmitters serotonin and norepinephrine, Elavil (imipramine) and Pamelor (nortriptyline) the two best known. Like MAOIs, the side effects can be burdensome, but because the drug operates with equal force on two neurotransmitters, some psychiatrists believe they may be more potent than the more popular single-action SSRIs.