Does Prozac increase the risk of PPH?
Anchors: No. Eli Lilly, the company that manufactures Prozac, has received only 8 reports of PPH in people taking Prozac out of 19 million users worldwide. This is even fewer cases than would be expected in the general population. The reason is that Prozac does not force the release of serotonin like fenfluramine does. It only blocks the reuptake. Prozac is also more than 98% protein-bound in the blood, whereas fenfluramine is much less protein-bound and so is more available to cause trouble. Hobbs: Will you comment on the letter from Bostwick and Brown (1996) regarding a toxic reaction from combining phentermine and Prozac. (Reference: Bostwick JM, Brown TM. A toxic reaction from combining fluoxetine and phentermine [letter]. Journal of Clinical Psychopharmacology, 1996 Apr, 16(2):189-90.) Anchors: First of all the phentermine was started at a dose of 30 mg, which should not be done. And second, the “toxic reaction” occurred 8 days after the Prozac was stopped. Hobbs: How does Phen-Pr
