Are aprotinin and heparin incompatible?
Bayer Corporation has recently received reports of Trasylol (aprotinin injection) incompatibility with heparin when added to the pump prime solution of bypass circuits. Analysis of these reports suggests that the noted incompatibilities were the result of high concentrations of Trasylol and heparin being added to non-recirculating reservoirs containing limited priming volumes. The compatibility of Trasylol, heparin, mannitol and corticosteroids have been demonstrated by Bayer Corporation in a pump prime solution of two liters total volume consisting of Plasma-Lyte A Injection, heparin 10,000 units, mannitol up to 30 g, Solu-Medrol up to 2 g, and Trasylol 2,000,000 KIU. While Trasylol is compatible with the above additives at 2 liters total volume and resulting concentrations, compatibility at lesser pump prime volumes has not been evaluated. To avoid incompatibility when adding Trasylol and heparin to the CPB pump prime, each agent must be added to the pump reservoir during recirculati
