What is autosomal recessive inheritance?
A single defective dysferlin gene cannot cause LGMD2B/Miyoshi. For the disease to occur, both copies of the dysferlin gene must be defective. Dysferlin is autosomal. This means that it is not a sex-linked gene, and both males and females are affected equally. One copy of the gene is inherited from each parent. If one good copy and one defective copy are inherited, the single good copy is sufficient for normal muscle function and the individual is only a carrier of the disease. If both parents are carriers, each child has a one in four (25%) chance of inheriting two defective copies of dysferlin and developing LGMD2B/Miyoshi.
