What causes pseudotumor cerebri?
The mechanism causing the elevated ICP is not well understood. Possible causes of pseudotumor cerebri include a defect in cerebral spinal fluid (CSF) absorption, increased cerebral swelling (edema) or increased cerebral blood volumes. Other factors which are possibly associated with this condition are recent weight gain, menstrual irregularities, and the presence of too much Vitamin A (hypervitaminosis A). Oral retinoid drugs and some antibiotics are other possible causes as is the stopping of steroid use after an extended period. Other conditions that have been associated with pseudotumour cerebri include renal failure, sleep apnea, and some lung diseases which lead to the retention of carbon dioxide. Less frequently, Guillain-Barre syndrome has been found to be associated. Infertility may result from irregular menstrual periods. Optic nerve swelling may lead to blindness if the intracranial pressure is not relieved.
