Are serum FLC levels prognostic?
In some instances yes. Elevated serum FLC levels have been shown to be an independent risk factor for progression to full multiple myeloma in monoclonal gammopathy of undetermined significance (MGUS).* A >50% reduction in serum FLC levels in response to therapy has been shown to predict longer remission in AL amyloidosis patients. Abnormal FLC ratios during IFE CR in post-transplant patients has been shown to be predictive of earlier relapse in two separate studies. Further work is being carried out to fully evaluate the importance of the last observations.
