What is the dose of Ferriprox®?
Ferriprox is approved over the dose range of 75-100 mg/kg/day. The most frequently used dose of Ferriprox® dose is 25 mg/kg three times daily, for a total daily dose of 75 mg/kg. For Ferriprox tablets, the dosage should be calculated to the nearest half tablet. For Ferriprox oral solution, the dose should be calculated to the nearest 2.5 mL increment. This dose stabilizes iron balance in the majority of transfusion-dependent patients (keeping in mind that iron excretion is dependent on both the dose of Ferriprox® and the initial iron load in the body). Increasing the dose up to 100 mg/kg/day provides greater excretion. Doses above 100 mg/kg/day are not currently recommended due to the potential for increased adverse reactions.
