How does the Golgi apparatus form?
There are different schools of thought concerning the formation of the Golgi apparatus. According to the vesicular shuttle model, the Golgi apparatus is an architectural structure that cannot be made from scratch. Insteady, newly-made proteins are packaged in the rough ER and are sent for further processing to a pre-existing structure (the Golgi) that is made up of different compartments. Opposing this is the cisternae maturation model which argues that the Golgi apparatus does indeed make itself from scratch. In this view, packages of processing enzymes and newly made proteins that originate in the ER fuse together to form the Golgi. As the proteins are processed and mature, they create the next Golgi compartment. Intriguing new data suggest that perhaps neither model is completely correct. This will likely lead to yet another hypothesis.
