How does PDF improve AP/MALDI?
PDF allows better transmission of ions into the API inlet, and thus higher sensitivity. Furthermore, peer-reviewed literature has shown that PDF makes AP/MALDI insensitive to laser misalignments of up to 1.2 mm off-axis, making the source much more robust. We offer these PDF benefits to our existing AP/MALDI users in the form of an external upgrade module. For our new users, we have integrated PDF directly into the ion source housing, and have called the new system “AP/MALDI PDF”. In these second generation AP/MALDI PDF systems, we have also made user-interface improvements that include: 1) enhanced image quality, 2) on-screen video capture and sample plate control, 3) faster sample spot changes, 4) new laser safety interlocks, 5) USB connectivity, and 6) full AB plate access. Modeling results showing ions focused into the API inlet using Pulsed Dynamic Focusing (PDF). Improved imaging with new, second generation, AP/MALDI PDF ion souces.
