We know that low levels of factor VIII activity constitutes hemophilia A, but are there any clinical manifestations of elevated factor VIII levels? How can a researcher measure elevated FVIII levels?
There is evidence that a high level of factor VIII is a risk factor for venous thrombosis. There are two articles in Thrombosis and Haemostasis 2000; volume 83: a) Kraaijenhagen et al. High plasma concentration of factor VIII:c is a major risk factor for venous thromboembolism (p. 5 9) b) ODonnell et al. Elevation of FVIII:c in venous thromboembolism is persistent and independent of the acute phase response (p. 10 13) Both of these recent articles discuss the issue of elevated factor VIII levels as a risk factor for venous thrombosis. An adaptation of Coamatic FVIII has been developed to allow accurate determination of elevated factor VIII levels. The method is in the Chromogenix 2000 catalog, and is for research use only.
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